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UHPLC Method for Ivermectin Determination

Method: HPLC-MS
Matrix: Medicine
Application No.: 101927
Componds: Ivermectin
Columns: Endeavorsil C18 1.8 μm 100 x 2.1 mm
Cat No.: 87003
Sample Pretreatment: Samples: Working solution of 0.4µg/mL was obtained by dilution of the stock solution with mobile phase. Standard solutions should be stored at 4℃.
Conditions: Mobile Phase: Acetonitrile / Methanol / 5 mM Ammonium formate in water (57 / 38 / 5)
Scan mode: ESI+;
Flow Rate: 0.25 mL/min;
Injection: 2 µL;
Temperature: 25℃
Publisher: Dikma Technologies Inc.
Keyword: Ivermectin, HPLC, UHPLC, Endeavorsil C18, COVID-19
Abstract: This methods provide simple and rapid determination of ivermectin and can be easily applied to drug development and clinical trial studies of this potential treatment.

 

Compounds

Concentration (µg/mL)

Retention Time(min)

MS→MS1 Ions

(Precursor→Product 1)

MS→MS2 Ions

(Precursor→Product 2)

Ivermectin

0.4

4.49

892.6 →569.4

892.6 → 307.2